Cutaneous T cell lymphoma

Description Cutaneous T cell lymphoma includes a group of rare cancers that involve th...

Description

Cutaneous T cell lymphoma includes a group of rare cancers that involve the skin. In these cancers, white blood cells attack the skin causing a variety of skin lesions. The most common forms of cutaneous T cell lymphoma are mycosis fungoides and Sézary syndrome. Cutaneous T cell lymphoma is more common in men and individuals with a sub-Saharan African heritage.

Symptoms

Symptoms vary depending on the type of cutaneous T Cell lymphoma. Symptoms include skin rashes that are dark or light and may mimic other more benign diseases such as eczema. Skin tumors may also be present, as well as swollen lymph nodes (lymphadenopathy) and itchy, red skin (erythroderma).

Tests

Common tests used for diagnosis and treatment

Workup:
A complete history and physical will be performed. Blood and imaging tests will likely be performed. A skin biopsy will likely be needed to help make the diagnosis.

Tests:
Complete blood count (CBC), Comprehensive metabolic panel (CMP), CT Scan, Positron emission tomography (PET) scan, Skin biopsy, Uric acid, Chest X-ray

Other Specific Tests: LDH (lactate dehydrogenase), HIV

Specialists:
Dermatology, Blood and Cancer Care (hematology and oncology), Pediatric Hematology and Oncology, Pediatric Dermatology, Telemedicine Dermatology

Treatment

Treatment varies depending on the severity of disease. For the skin, topical corticosteroids, retinoids, chemotherapy and light therapy may be used. Treatment may also include systemic chemotherapy, retinoids, and/or biological therapies, such as interferon and monoclonal antibodies. Radiation therapy, surgical removal and bone marrow transplantation may also be performed.