Description Factor X (ten) defi...
Description
Factor X (ten) deficiency is a rare inherited or acquired deficiency of clotting factor X. This deficiency usually presents with unusual bleeding including recurring nosebleeds, bruising, blood in the urine or excessive bleeding during surgery or trauma. Bleeding may range from mild to severe depending on the extent of the deficiency. The congenital deficiency is an inherited disorder, leading to a life-long condition. Later in life factor X deficiency (called acquired factor X deficiency) can develop in people with liver disease, vitamin K deficiency, vitamin K antagonist use, or amyloidosis. Inherited factor X deficiency affects 1 in 500,000 people.
Symptoms
Symptoms vary but include recurring nosebleeds, easy bruising, blood in the urine, bleeding in the brain or excessive bleedings during or following surgery or trauma.
Tests
Common tests used for diagnosis and treatment
Workup:
A history and physical exam will be performed. Coagulation studies are usually performed and workup for underlying disease may be performed if thought to be an acquired deficiency.
Tests:
Bleeding time, Complete blood count (CBC), Activated partial thromboplastin (aPTT or PTT), Prothrombin test (PT, INR), Factor X assay
Other Specific Tests: Vitamin K, Comprehensive Metabolic Panel (CMP), Liver Ultrasound
Specialists:
Internal Medicine, Family Practice, Blood and Cancer Care (hematology and oncology), Pediatric Hematology and Oncology, Clinical Genetics, Hepatology
Workup:
A history and physical exam will be performed. Coagulation studies are usually performed and workup for underlying disease may be performed if thought to be an acquired deficiency.
Tests:
Bleeding time, Complete blood count (CBC), Activated partial thromboplastin (aPTT or PTT), Prothrombin test (PT, INR), Factor X assay
Other Specific Tests: Vitamin K, Comprehensive Metabolic Panel (CMP), Liver Ultrasound
Specialists:
Internal Medicine, Family Practice, Blood and Cancer Care (hematology and oncology), Pediatric Hematology and Oncology, Clinical Genetics, Hepatology
Treatment
Treatment depends on the severity of the factor X deficiency. Restoring factor X levels to 10-40% of normal is usually the goal. Immediate treatment for bleeding may include fresh frozen plasma, prothrombin complex concentrates and/or vitamin K administration. Treatment of the underlying disease may resolve the acquired disorder.